Inverse Vaccines

A paradigm shift in the fight against diseases.

Toleration vs. Attacking

It's a pretty mature concept, but in the realm of diseases and disease treatment, it's potentially game-changing.

In a good way.

A new concept called "inverse vaccines" or "tolerogenic vaccines" is becoming a reality, and with it comes a fundamental change not only in how we treat disease but also how we live with the concept of disease.

These treatments aim to train the immune system to tolerate certain substances instead of attacking them, which is the opposite approach of traditional vaccines. While typical vaccines prime the immune system to respond against pathogens, inverse vaccines teach the immune system to stand down and ignore specific targets.

If successful, inverse vaccines could offer a more targeted approach than broadly immunosuppressive drugs, dampening the immune response only to specific antigens without increasing vulnerability to infections.

This could lead to new therapies for autoimmune diseases like multiple sclerosis and celiac disease, where the immune system mistakenly attacks the body's own proteins.

After the break, we will get into a specific use case - how inverse vaccines are leading to reversals in the fight against multiple sclerosis.